Hyperlipid

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Fructose (06) Acipimox tangent

I've glibly stated that I consider insulin resistance to be a simple but imperfect adaptation to the inability of insulin to suppress basal ...

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Metformin (14) Normals

One of the flakiest aspects of Protons is the concept that the glycerophosphate shuttle transforms cytoplasmic NADH in to a mitochondrial FA...

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How can insulin resistance cause weight gain? (5) MCTs

The problems posed to the Protons hypothesis by the failure of fully hydrogenated coconut oil to suppress obesity in rodent models continues...

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How can insulin resistance cause weight gain? (2) 0.1 μM

When you type adipocyte + 4-HNE to Pubmed, this is your first hit 4-hydroxynonenal causes impairment of human subcutaneous adipogenesis and ...

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How can insulin resistance cause weight gain? (1) ALDH2

Mea culpa. Sorry all for neglected comments else where on the blog and IRL. Blame Tucker for this link in here ... Here's the next post. Th...

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Delta psi and ROS

I'll post this now as I've gone off down a related but more concise rabbit hole for the next posts. Okay. Here are a couple more building bl...

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Warning: Politics

Over the years I have only very rarely touched upon politics, outside of the corruption intrinsic to certain types of scientific publication...

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Choose your insulin sensitivity well

People may or may not realise that I dislike meta-analysis. In the words of the great Malcolm Kendrick "One, two, skip a few, 99, one hundre...

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Brand on 4-HNE facilitated uncoupling

This is one of those papers with strong confirmation bias reinforcing properties, so care is needed. I do indeed have some difficulties with...

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Beta oxidation intermediates control ETC function

Back to the paper provided by met4health, briefly mentioned previously: Electron Transport Chain-dependent and -independent Mechanisms of Mi...